Trimethylsilyldiazomethane → HCID 86669289, 화합물
반응식
[CH3:1][Si](C=[N+]=[N-])(C)C.[Cl:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([OH:15])=[O:14])=[C:11]([O:18][CH2:19][CH:20]([F:22])[F:21])[N:10]=1>CO.C(Cl)Cl>[CH3:1][O:14][C:13](=[O:15])[C:12]1[CH:16]=[CH:17][C:9]([Cl:8])=[N:10][C:11]=1[O:18][CH2:19][CH:20]([F:21])[F:22]참가 물질
5
실험 절차
Trimethylsilyl diazomethane (2 M in hexane; 15.0 mL, 30.0 mmol) is added to a mixture of 6-chloro-2-(2,2-difluoro-ethoxy)-nicotinic acid (6.0 g, 25.3 mmol) in MeOH (50 mL) and DCM (100 mL). The reaction mixture is stirred at rt for 10 min, quenched with AcOH and concentrated. The residue is diluted with water and filtered. The filtercake is washed with water and dried at 40° C.
후처리
- customquenched with AcOH
- concentrationconcentrated
- additionThe residue is diluted with water
- filtrationfiltered
- washThe filtercake is washed with water
- customdried at 40° C.
출처 및 근거
- ORD 기록
- ord-dd8e0126a1ee4d858b9efa63586726e5
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08586604B2
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