Nitric Acid → HCID 86669290, 화합물
반응식
[N+:1]([O-:4])(O)=[O:2].[CH3:5][O:6][C:7](=[O:20])[C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[N:10][C:9]=1[O:15][CH2:16][CH:17]([F:19])[F:18]>OS(O)(=O)=O>[CH3:5][O:6][C:7](=[O:20])[C:8]1[CH:13]=[C:12]([N+:1]([O-:4])=[O:2])[C:11]([Cl:14])=[N:10][C:9]=1[O:15][CH2:16][CH:17]([F:19])[F:18]참가 물질
4
실험 절차
Fuming HNO3 (25 mL) is added at rt to 6-chloro-2-(2,2-difluoro-ethoxy)-nicotinic acid methyl ester (10.7 g, 42.5 mmol) in concentrated H2SO4 (50 mL) and stirred for 10 min. The reaction mixture is added dropwise to ice water, stirred and filtered. The filtercake is washed with water and dried at 50° C.
후처리
- stirringstirred
- filtrationfiltered
- washThe filtercake is washed with water
- customdried at 50° C.
출처 및 근거
- ORD 기록
- ord-af8a17d0cedc4e7d932596a1f7c8ade4
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08586604B2
반응 노트
불러오는 중…