Pivaloyl chloride → N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide

HRID 2042811노트

반응식

HRID 2042811 반응식
[C:1](Cl)(=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3].[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH2:14])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]>C1COCC1>[Cl:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][NH:14][C:1](=[O:6])[C:2]([CH3:5])([CH3:4])[CH3:3])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

참가 물질

4

반응물 2

HCID 62493Pivaloyl chlorideHCID 18796740(4-Chloro-3-nitrophenyl)methanamine

생성물 1

HCID 66765017N-(4-Chloro-3-nitrobenzyl)-2,2-dimethyl-propionamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

TEA (8.00 mL, 57.5 mmol) followed by pivaloyl chloride (2.80 mL, 22.8 mmol) in THF (25 mL) are added to 4-chloro-3-nitrobenzylamine (5.00 g) in THF (100 mL). The reaction mixture is diluted with THF and stirred at rt for 1.5 h. The mixture is filtered and washed and the filtrate is concentrated.

후처리

  1. filtrationThe mixture is filtered
  2. washwashed
  3. concentrationthe filtrate is concentrated

출처 및 근거

ORD 기록
ord-82f6152cfeb04c0cbbad98eea7d5d7ae
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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