Acetonitrile → N-(4-Chloro-3-{[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-2-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide

HRID 2042812노트

반응식

HRID 2042812 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[N:16]=[C:17]=[S:18].N[C:20]1[C:21]([NH:41][CH3:42])=[N:22][C:23]([O:36][CH2:37][CH:38]([F:40])[F:39])=[C:24]([CH:35]=1)[C:25]([NH:27][C:28]1[CH:33]=[CH:32][C:31]([Br:34])=[CH:30][CH:29]=1)=[O:26].CC#[N:45]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[NH:16][C:17]([NH:45][C:23]1([O:36][CH2:37][CH:38]([F:40])[F:39])[C:24]([C:25](=[O:26])[NH:27][C:28]2[CH:33]=[CH:32][C:31]([Br:34])=[CH:30][CH:29]=2)=[CH:35][CH:20]=[C:21]([NH:41][CH3:42])[NH:22]1)=[S:18]

참가 물질

4

반응물 3

HCID 6342AcetonitrileHCID 86646343HCID 86646343, 화합물HCID 866648925-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide

생성물 1

HCID 86669292N-(4-Chloro-3-{[3-(4-bromo-phenylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-2-yl]-thioureido}-benzyl)-2,2-dimethyl-propionamide

실험 절차

N-(4-Chloro-3-isothiocyanatobenzyl)-2,2-dimethyl-propionamide (66 mg, 0.23 mmol) is added to 5-amino-N-(4-bromo-phenyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-nicotinamide (93 mg, 0.23 mmol) in MeCN (3.5 mL) and stirred at rt overnight. The reaction mixture is filtered and the filtercake is dried.

후처리

  1. filtrationThe reaction mixture is filtered
  2. customthe filtercake is dried

출처 및 근거

ORD 기록
ord-1552cf0d52a247f295881565a93008dc
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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