HCID 86646343, 화합물 → HCID 178482446, 화합물

HRID 2042818노트

반응식

HRID 2042818 반응식
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[N:16]=[C:17]=[S:18].[NH2:19][C:20]1[C:21]([NH:44][CH3:45])=[N:22][C:23]([O:39][CH2:40][CH:41]([F:43])[F:42])=[C:24]([CH:38]=1)[C:25]([NH:27][C@H:28]1[CH2:33][CH2:32][C@H:31]([C:34]([F:37])([F:36])[F:35])[CH2:30][CH2:29]1)=[O:26]>CC#N>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][NH:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:4][C:3]=1[NH:16][C:17]([NH:19][C:20]1[CH:38]=[C:24]([C:25](=[O:26])[NH:27][C@H:28]2[CH2:33][CH2:32][C@H:31]([C:34]([F:37])([F:35])[F:36])[CH2:30][CH2:29]2)[C:23]([O:39][CH2:40][CH:41]([F:42])[F:43])=[N:22][C:21]=1[NH:44][CH3:45])=[S:18]

참가 물질

4

반응물 2

HCID 86646343HCID 86646343, 화합물HCID 178482445HCID 178482445, 화합물

생성물 1

HCID 178482446HCID 178482446, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

N-(4-Chloro-3-isothiocyanatobenzyl)-2,2-dimethyl-propionamide (68 mg, 0.24 mmol) is added to 5-amino-2-(2,2-difluoro-ethoxy)-6-methylamino-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (95 mg, 0.24 mmol) in MeCN (3.5 mL) and stirred at rt overnight. The reaction mixture is concentrated and used directly in the next step without further purification.

후처리

  1. concentrationThe reaction mixture is concentrated
  2. customused directly in the next step without further purification

출처 및 근거

ORD 기록
ord-ce59b1bd9d694902b692a36ae209060c
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

반응 노트

불러오는 중…