Diisopropylcarbodiimide → HCID 178481212, 화합물

HRID 2042819노트

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HRID 2042819 반응식
CC(C)N=C=NC(C)C.[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][C:12]=1[NH:25][C:26]([NH:28][C:29]1[CH:30]=[C:31]([C:42](=[O:54])[NH:43][C@H:44]2[CH2:49][CH2:48][C@H:47]([C:50]([F:53])([F:52])[F:51])[CH2:46][CH2:45]2)[C:32]([O:37][CH2:38][CH:39]([F:41])[F:40])=[N:33][C:34]=1[NH:35][CH3:36])=S>CC#N>[Cl:10][C:11]1[CH:24]=[CH:23][C:14]([CH2:15][NH:16][C:17](=[O:22])[C:18]([CH3:21])([CH3:20])[CH3:19])=[CH:13][C:12]=1[NH:25][C:26]1[N:35]([CH3:36])[C:34]2=[N:33][C:32]([O:37][CH2:38][CH:39]([F:41])[F:40])=[C:31]([C:42](=[O:54])[NH:43][C@H:44]3[CH2:49][CH2:48][C@H:47]([C:50]([F:53])([F:52])[F:51])[CH2:46][CH2:45]3)[CH:30]=[C:29]2[N:28]=1

참가 물질

4

반응물 2

HCID 12734DiisopropylcarbodiimideHCID 178482446HCID 178482446, 화합물

생성물 1

HCID 178481212HCID 178481212, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

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온도
60 °C

실험 절차

DIC (40 μL, 0.24 mmol) is added to a mixture of N-{4-chloro-3-[3-(trans-4-trifluoromethyl-cyclohexylcarbamoyl)-2-(2,2-difluoro-ethoxy)-6-methylamino-pyridin-5-ylthioureido]benzyl}-2,2-dimethyl-propionamide (135 mg, 0.20 mmol) and MeCN (3.5 mL). The reaction mixture is stirred at 60° C. overnight, allowed to cool and concentrated. The residue is treated with MeCN, filtered off and dried.

후처리

  1. temperatureto cool
  2. concentrationconcentrated
  3. additionThe residue is treated with MeCN
  4. filtrationfiltered off
  5. customdried

출처 및 근거

ORD 기록
ord-f6849ae1aa4b41d5924c0b797305cc8f
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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