2-Methoxyethanol → HCID 178496180, 화합물

HRID 2042820노트

반응식

HRID 2042820 반응식
[CH3:1][O:2][CH2:3][CH2:4][OH:5].CC([O-])(C)C.[K+].Cl[C:13]1[N:31]=[C:30]([Cl:32])[CH:29]=[CH:28][C:14]=1[C:15]([NH:17][C@H:18]1[CH2:23][CH2:22][C@H:21]([C:24]([F:27])([F:26])[F:25])[CH2:20][CH2:19]1)=[O:16]>C1COCC1.O>[Cl:32][C:30]1[CH:29]=[CH:28][C:14]([C:15]([NH:17][C@H:18]2[CH2:23][CH2:22][C@H:21]([C:24]([F:27])([F:26])[F:25])[CH2:20][CH2:19]2)=[O:16])=[C:13]([O:5][CH2:4][CH2:3][O:2][CH3:1])[N:31]=1

참가 물질

6

반응물 3

HCID 80192-MethoxyethanolHCID 23665647Potassium tert-butoxideHCID 178523747HCID 178523747, 화합물

생성물 1

HCID 178496180HCID 178496180, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

2-Methoxyethanol (550 μL, 6.94 mmol) is added at rt to KOtBu (750 mg, 6.35 mmol) in THF (30 mL) and it is stirred for 5 min. 2,6-Dichloro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (2.00 g, 5.86 mmol) is added to the reaction mixture and it is stirred for 10 min at rt. The reaction mixture is diluted with water, filtered and the filtrate is concentrated. The residue is treated with water, filtered off, washed with water and dried.

후처리

  1. stirringis stirred for 10 min at rt
  2. filtrationfiltered
  3. concentrationthe filtrate is concentrated
  4. additionThe residue is treated with water
  5. filtrationfiltered off
  6. washwashed with water
  7. customdried

출처 및 근거

ORD 기록
ord-043e2677ff7045c3a922bf56bde1255e
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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