Methylamine → HCID 178482449, 화합물

HRID 2042824노트

반응식

HRID 2042824 반응식
[CH3:1][NH2:2].Cl[C:4]1[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][C:7]([C:8]([NH:10][C@H:11]2[CH2:16][CH2:15][C@H:14]([C:17]([F:20])([F:19])[F:18])[CH2:13][CH2:12]2)=[O:9])=[C:6]([O:26][CH2:27][CH2:28][O:29][CH3:30])[N:5]=1>C1COCC1.O>[CH3:30][O:29][CH2:28][CH2:27][O:26][C:6]1[N:5]=[C:4]([NH:2][CH3:1])[C:22]([N+:23]([O-:25])=[O:24])=[CH:21][C:7]=1[C:8]([NH:10][C@H:11]1[CH2:16][CH2:15][C@H:14]([C:17]([F:20])([F:19])[F:18])[CH2:13][CH2:12]1)=[O:9]

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 178496181HCID 178496181, 화합물

생성물 1

HCID 178482449HCID 178482449, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Methylamine (2 M in THF; 400 μL, 0.80 mmol) is added to 6-chloro-2-(2-methoxy-ethoxy)-5-nitro-N-(trans-4-trifluoromethyl-cyclohexyl)-nicotinamide (150 mg, 0.35 mmol) in THF (10 mL). After 45 min at rt the reaction mixture is diluted with water, concentrated and filtered. The filtercake is washed with water and dried.

후처리

  1. concentrationconcentrated
  2. filtrationfiltered
  3. washThe filtercake is washed with water
  4. customdried

출처 및 근거

ORD 기록
ord-7c25da5ce18342c590f3839c9b30abac
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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