2-Fluoroethanol → HCID 178523748, 화합물

HRID 2042827노트

반응식

HRID 2042827 반응식
[F:1][CH2:2][CH2:3][OH:4].CC(C)([O-])C.[K+].Cl[C:12]1[N:30]=[C:29]([Cl:31])[CH:28]=[CH:27][C:13]=1[C:14]([NH:16][CH:17]1[CH2:22][CH2:21][CH:20]([C:23]([F:26])([F:25])[F:24])[CH2:19][CH2:18]1)=[O:15]>C1COCC1.O>[Cl:31][C:29]1[CH:28]=[CH:27][C:13]([C:14]([NH:16][C@H:17]2[CH2:18][CH2:19][C@H:20]([C:23]([F:24])([F:25])[F:26])[CH2:21][CH2:22]2)=[O:15])=[C:12]([O:4][CH2:3][CH2:2][F:1])[N:30]=1

참가 물질

6

반응물 3

HCID 97372-FluoroethanolHCID 23665647Potassium tert-butoxideHCID 86669299HCID 86669299, 화합물

생성물 1

HCID 178523748HCID 178523748, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

2-Fluoroethanol (380 μL, 6.45 mmol) is added to potassium tert-butoxide (730 mg, 6.16 mmol) in THF (60 mL) and stirred for 5 min at rt. After the addition of 2,6-dichloro-N-(4-trifluoromethyl-cyclohexyl)-nicotinamide (2.00 g, 5.86 mmol) the reaction mixture is stirred for 1 h hour at rt, then diluted with water and concentrated. The residue is stirred in ice water, the precipitate is filtered off and dried.

후처리

  1. stirringis stirred for 1 h hour at rt
  2. concentrationconcentrated
  3. stirringThe residue is stirred in ice water
  4. filtrationthe precipitate is filtered off
  5. customdried

출처 및 근거

ORD 기록
ord-dc7ec1cc6de448e2b416d666e5bd0b3e
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586604B2

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