홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,2-Dichloroethane → HCID 86669314, 화합물

HRID 2042843
노트
인쇄 미리보기

반응식

HRID 2042843 반응식
[Cl:1][C:2]1[C:15]([N:16]=[C:17]=S)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8].[CH3:20][O:21][C:22](=[O:36])[C:23]1[CH:28]=[C:27]([NH2:29])[C:26]([NH2:30])=[N:25][C:24]=1[O:31][CH2:32][CH:33]([F:35])[F:34].C(Cl)CCl>CC#N.O>[Cl:1][C:2]1[C:15]([NH:16][C:17]2[NH:29][C:27]3[C:26]([N:30]=2)=[N:25][C:24]([O:31][CH2:32][CH:33]([F:35])[F:34])=[C:23]([C:22]([O:21][CH3:20])=[O:36])[CH:28]=3)=[C:14]([Cl:19])[CH:13]=[CH:12][C:3]=1[CH2:4][NH:5][C:6](=[O:11])[C:7]([CH3:10])([CH3:9])[CH3:8]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 111,2-DichloroethaneHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 86664894HCID 86664894, 화합물

생성물 1

HCID 86669314HCID 86669314, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 6342Acetonitrile용매

실험 절차

A mixture of N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide (4.00 g, 12.6 mmol) and 5,6-diamino-2-(2,2-difluoro-ethoxy)-nicotinic acid methyl ester (3.10 g, 12.5 mmol, prepared according to WO2010/034799) in MeCN (30 ml) is stirred for 2.5 h, then EDC (2.75 g, 14.3 mmol) is added and it is stirred at reflux for 15 min. The mixture is diluted with water, concentrated and extracted with DCM. The organic phase is dried with MgSO4, filtered and concentrated.

후처리

  1. stirringit is stirred
  2. temperatureat reflux for 15 min
  3. concentrationconcentrated
  4. extractionextracted with DCM
  5. dry with materialThe organic phase is dried with MgSO4
  6. filtrationfiltered
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-06751cc7edc94f198fbe9581d5a272d5
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08586604B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트