Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester → HCID 178423965, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester | HCID 2729196 | — |
| 반응물 | Purine, 6-bromo- | HCID 5287830 | — |
| 반응물 | 2-Amino-6-bromopurine | HCID 6101139 | — |
| 반응물 | (2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoate | HCID 12961228 | — |
| 반응물 | HCID 178423963 | HCID 178423963 | — |
| 반응물 | HCID 178456854 | HCID 178456854 | — |
| 용매 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | HCID 178423965 | HCID 178423965 | — |
반응 단계
Compound 68 was prepared using the general procedure described above with respect to compound 14, but 2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, and 2-amino-6-bromopurine was substituted for 6-bromopurine in step D. The obtained 2-[1-(2-amino-9H-purin-6-ylamino)-2-tert-butoxy-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one was then dissolved in trifluoroacetic acid and allowed to stir at ambient temperature for 5 hours. Purification by LC provided the product 68 as a white solid. MS (ES): m/z 429 (M+H), 215, 206, 151. Compound 68 is shown below.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08586597B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-0d3f7d5aaf76484c9666513c7a18cc96 |
| 출처 메모 | uspto-grants-2013_11 |