Purine, 6-bromo- → HCID 178463608, 화합물

HRID 2042866

반응식

HRID 2042866 반응식
[F:1][C:2]1[CH:3]=[C:4]([N:9]2[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=[C:10]2[CH:20]([NH:22][C:23]2[N:31]=[CH:30][N:29]=[C:28]3[C:24]=2[N:25]=[CH:26][NH:27]3)[CH3:21])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:32]C1N=C2C(NC=N2)=C(Br)N=1.BrC1N=CN=C2C=1NC=N2.BrC1C2C(NC(C3N(C4C=CC=C(F)C=4)C(=O)C4C(=CC=CC=4C)N=3)C)=NC=NC=2NC=1>>[NH2:32][C:30]1[N:29]=[C:28]2[C:24]([N:25]=[CH:26][NH:27]2)=[C:23]([NH:22][CH:20]([C:10]2[N:9]([C:4]3[CH:3]=[C:2]([F:1])[CH:7]=[C:6]([F:8])[CH:5]=3)[C:18](=[O:19])[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]=2)[CH3:21])[N:31]=1

참가 물질

5

반응물 4

HCID 5287830Purine, 6-bromo-HCID 61011392-Amino-6-bromopurineHCID 115984082-[1-(5-bromo-7H-pyrrolo [2,3-d]pyrimidin-4-ylamino)-ethyl]-3-(3-fluoro-phenyl)-5-methyl-3H-quinazolin-4-oneHCID 178463554HCID 178463554, 화합물

생성물 1

HCID 178463608HCID 178463608, 화합물

실험 절차

Compound 99 was prepared using the general procedure described above with respect to compound 95, but 2-amino-6-bromopurine was substituted for 6-bromopurine in step D. ESI-MS m/z 435 (MH+). Compound 96 is shown below.

출처 및 근거

ORD 기록
ord-ddb0846aab0941b7bb2d15f83a6496d2
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586597B2

연결된 노트

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