Diallyl Disulfide → HCID 178460777, 화합물

HRID 2043038

반응식

HRID 2043038 반응식
[CH3:1][S:2][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][NH:6][CH:7]=1.[CH2:14](SSCC=C)[CH:15]=C.IC1C(C2C=NC=CC=2)=NNC=1>C(OCC)(=O)C>[CH2:1]([S:2][C:3]1[C:4]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[N:5][NH:6][CH:7]=1)[CH:14]=[CH2:15]

참가 물질

5

반응물 3

HCID 16590Diallyl DisulfideHCID 178503312HCID 178503312, 화합물HCID 178506560HCID 178506560, 화합물2회

생성물 1

HCID 178460777HCID 178460777, 화합물수율 27%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Compound 21Q was prepared following the procedure as described for the synthesis of compound 21A (see Scheme 3) using 3-allyldisulfanyl-propene as the disulfide and 3-(4-iodo-1H-pyrazol-3-yl)-pyridine (compound 20B). (conditions flash chromatography (ethyl acetate)) Yield: 27%. (oil). 1H-NMR (200 MHz, CDCl3): δ 9.20 (d, J=2 Hz, 1H), 8.60 (dd, J=5 Hz, 2 Hz, 1H), 8.29 (dt, J=8 Hz, 2 Hz, 1H), 7.70 (s, 1H), 7.40-7.36 (m, 1H), 5.77-5.66 (m, 1H), 4.94 (bdd, J=11 Hz, 1 Hz, 1H), 4.83 (bdd, J=17 Hz, 1 Hz, 1H), 3.19 (bd, J=8 Hz, 2H).

출처 및 근거

ORD 기록
ord-e65cebeeff294be38eb62aa339439c6d
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586606B2

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