홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Ethanolamine → N-[4-(4-Acetyl-1-oxa-4,7-diazaspiro[4,4]non-7-yl)phenyl]-4-butoxybenzamide

HRID 2043095
노트
인쇄 미리보기

반응식

HRID 2043095 반응식
[CH2:1]([O:5][C:6]1[CH:26]=[CH:25][C:9]([C:10]([NH:12][C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:23][CH2:22][C:21](=[O:24])[CH2:20]3)=[CH:15][CH:14]=2)=[O:11])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[CH2:27]([CH2:29][NH2:30])O.C(=O)([O-])[O-].[K+].[K+].[C:37](Cl)(=[O:39])[CH3:38]>ClCCl>[C:37]([N:30]1[C:21]2([CH2:22][CH2:23][N:19]([C:16]3[CH:17]=[CH:18][C:13]([NH:12][C:10](=[O:11])[C:9]4[CH:25]=[CH:26][C:6]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[CH:7][CH:8]=4)=[CH:14][CH:15]=3)[CH2:20]2)[O:24][CH2:27][CH2:29]1)(=[O:39])[CH3:38]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 700EthanolamineHCID 6367Acetyl chlorideHCID 11430Potassium CarbonateHCID 21105481HCID 21105481, 화합물

생성물 1

HCID 59558092N-[4-(4-Acetyl-1-oxa-4,7-diazaspiro[4,4]non-7-yl)phenyl]-4-butoxybenzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매
2회

실험 절차

A mixture of 4-butoxy-N-[4-(3-oxopyrrolidin-1-yl)phenyl]benzamide (70 mg), ethanolamine (12 mg), potassium carbonate (27 mg) and dichloromethane (3 ml) was stirred for 48 hours, and then acetyl chloride (16 mg) was added. After 20 hours, the mixture was diluted with dichloromethane, washed with water, dried over magnesium sulfate and concentrated. The residue was purified by preparative HPLC. The product with the molecular weight of 437.54 (C25H31N3O4); MS (ESI): 438 (M+H+) was obtained in this way.

후처리

  1. waitAfter 20 hours
  2. washwashed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. customThe residue was purified by preparative HPLC
  6. customMS (ESI): 438 (M+H+) was obtained in this way

출처 및 근거

ORD 기록
ord-597ce4032acf40d3a7a946559e853a1d
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08586609B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트