Ammonium Chloride → 1-(2,6-Dichloropyridin-4-YL)ethanone
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:11]=[C:12]([Cl:14])[N:13]=1)[C:5](N(OC)C)=[O:6].O1CCC[CH2:16]1.C[Mg]Br.[Cl-].[NH4+]>O1CCCC1.C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([C:5](=[O:6])[CH3:16])[CH:11]=[C:12]([Cl:14])[N:13]=1참가 물질
6
반응 조건
- 온도
- 0 °C
실험 절차
490 mg of 2,6-dichloro-N-methoxy-N-methyl isonicotinamide was dissolved in tetrahydrofuran, 2.1 ml of 3M methyl magnesium bromide tetrahydrofuran solution was added dropwise at 0° C., and the mixture was stirred at 0° C. for 1 hour. To the reaction solution was added ammonium chloride aqueous solution, and the mixture was diluted with ethyl acetate. The mixture was washed with brine, and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 325 mg of the objective compound.
후처리
- washThe mixture was washed with brine
- dry with materialdried over magnesium sulfate
- distillationThe solvent was distilled off under reduced pressure
출처 및 근거
- ORD 기록
- ord-be0deae52f7643fcb73b1d27650ea9e1
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08586591B2
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