Benzene, (3-iodopropyl)- → 2-(4-Phenylbutyl)nicotinic acid

HRID 2044150

반응식

HRID 2044150 반응식
[CH3:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].I[CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[C:15]1([CH2:14][CH2:13][CH2:12][CH2:1][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

참가 물질

3

반응물 2

HCID 138121Benzene, (3-iodopropyl)-HCID 6433732-Methylnicotinic acid

생성물 1

HCID 671341912-(4-Phenylbutyl)nicotinic acid수율 75.3%

실험 절차

Starting from 2.1 g (15.0 mmol) of 2-methyl-nicotinic acid and 5.5 g (22.5 mmol) of 1-iodo-3-phenyl-propane, 2.9 g (11.3 mmol, 75%) of 2-(4-phenylbutyl)nicotinic acid were obtained according to the process described in precursor VB006.

출처 및 근거

ORD 기록
ord-528b67ab7b9f48b6a729abad8aa455e9
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08586755B2

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