4-Toluenesulfonyl chloride → HCID 59287022, 화합물

HRID 2045711노트

반응식

HRID 2045711 반응식
C1(C)C=CC(S(Cl)(=O)=[O:8])=CC=1.[Br:12][C:13]1[CH:14]=[N+:15]([O-])[C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[C:18]([O:23][CH3:24])[CH:17]=2>CCOC(C)=O.C([O-])([O-])=O.[K+].[K+]>[Br:12][C:13]1[C:14](=[O:8])[NH:15][C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[C:18]([O:23][CH3:24])[CH:17]=2

참가 물질

5

반응물 2

HCID 73974-Toluenesulfonyl chlorideHCID 592871093-Bromo-7-methoxyquinoline 1-oxide

생성물 1

HCID 59287022HCID 59287022, 화합물

시약·촉매·용매 2

HCID 8857Ethyl Acetate용매HCID 11430Potassium Carbonate용매

실험 절차

p-Toluenesulfonyl chloride (1.68 g, 8.83 mmol) was added to a solution of 3-bromo-7-methoxyquinoline 1-oxide (2.04 g, 8.03 mmol) in EtOAc (50 mL) and 15% aqueous K2CO3 (15 mL) at RT. The reaction mixture was stirred vigorously at RT for 18 h, at which time the product was collected by filtration and washed with EtOAc. The solid was dried under vacuum and used with no further purification. LRMS (M+H)+=254.1.

후처리

  1. filtrationwas collected by filtration
  2. washwashed with EtOAc
  3. customThe solid was dried under vacuum
  4. customused with no further purification

출처 및 근거

ORD 기록
ord-9c0506d48e0f4e5fab57e0d1f765f908
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08591878B2

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