Potassium Carbonate → HCID 46916504, 화합물

HRID 2045939노트

반응식

HRID 2045939 반응식
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([C:12]2[CH:21]=[N:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[N:13]=2)[CH:7]=1)=[O:4].C(=O)([O-])[O-].[K+].[K+].[N:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]2)=[CH:30][CH:29]=1>C(#N)C>[N:28]1[CH:33]=[CH:32][C:31]([N:34]2[CH2:35][CH2:36][N:37]([CH2:2][C:3]([NH:5][C:6]3[CH:11]=[CH:10][CH:9]=[C:8]([C:12]4[CH:21]=[N:20][C:19]5[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=5)[N:13]=4)[CH:7]=3)=[O:4])[CH2:38][CH2:39]2)=[CH:30][CH:29]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 705171-(4-Pyridyl)piperazineHCID 46916455HCID 46916455, 화합물

생성물 1

HCID 46916504HCID 46916504, 화합물수율 24.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 2-bromo-N-(3-(quinoxalin-2-yl)phenyl)acetamide (100 mg, 0.292 mmol), potassium carbonate (51 mg, 0.365 mmol) and 1-(4-pyridyl)-piperazine (50 mg, 0.307 mmol) in acetonitrile (5 mL) was heated at reflux for 15 min. The solvent was evaporated in vacuo and the crude reaction mixture was purified by preparative LCMS to afford 2-(4-(pyridin-4-yl)piperazin-1-yl)-N-(3-(quinoxalin-2-yl)phenyl)acetamide (30 mg, 24% yield). LCMS calculated for C25H24N6O (M+H): 425.50. found 425.44. 1H-NMR (DMSO-d6, 400 Mhz) δH: 10.04 (1H, br.), 9.52 (1H, s), 8.58 (1H, m), 8.15-8.10 (4H, m), 8.05-8.08 (1H, m), 7.82-7.95 (3H, m), 7.55-7.60 (1H, m), 6.85 (2H, m), 3.45 (4H, m), 3.25 (2H, s), 2.72 (4H, m).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 15 min
  3. customThe solvent was evaporated in vacuo
  4. customthe crude reaction mixture
  5. customwas purified by preparative LCMS

출처 및 근거

ORD 기록
ord-a0fc12bdfc3440ac9486089975c2c738
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592415B2

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