4-((6-Methoxybenzofuran-2-yl)ethynyl)phenyl acetate → 4-(2-(6-Methoxy-2,3-dihydrobenzofuran-2-yl)ethyl)phenol
반응식
C([O:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]#[C:12][C:13]2[O:14][C:15]3[CH:21]=[C:20]([O:22][CH3:23])[CH:19]=[CH:18][C:16]=3[CH:17]=2)=[CH:7][CH:6]=1)(=O)C.CC1(C)C2CC1CCC2NS(C1C=CC(C#CCCO)=CC=1)(=O)=O>>[CH3:23][O:22][C:20]1[CH:19]=[CH:18][C:16]2[CH2:17][CH:13]([CH2:12][CH2:11][C:8]3[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=3)[O:14][C:15]=2[CH:21]=1참가 물질
3
실험 절차
When the product of Step A was substituted for N-(6,6-dimethyl bicyclo[3.1.1]heptan-2-yl)-4-(4-hydroxybut-1-ynyl)benzenesulphonamide in Example 18, Step C, the similar process (higher pressure of H2) afforded the title compound in 96% yield, as creamy paste. 1H-NMR (CDCl3) 7.25-7.19 (m, 2H); 7.02-6.97 (m, 3H); 6.38-6.35 (m, 2H); 4.81-4.72 (m, 1H); 3.75 (s, 3H); 3.24-3.16 (m, 1H); 2.83-2.73 (m, 3H); 2.27 (s, 3H); 2.13-2.07 (m, 1H); 2.06-1.92 (m, 1H).
출처 및 근거
- ORD 기록
- ord-72bbeb0f89e846f8b969a7fa2b0a4bf1
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08592399B2
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