4-Methyloxybenzyl chloride → 2-Hydroxymethyl-5-(4-methoxy-benzyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

반응식

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][C:6]([CH2:7]Cl)=[CH:5][CH:4]=1.C([O:13][C:14]([C:16]1[CH:29]=[C:19]2[C:20](=[O:28])[N:21](CC3CC3)[CH2:22][CH2:23][N:18]2[N:17]=1)=O)C.C1(CN2CCN3N=C(CO)C=C3C2=O)CC1>>[OH:13][CH2:14][C:16]1[CH:29]=[C:19]2[C:20](=[O:28])[N:21]([CH2:7][C:6]3[CH:9]=[CH:10][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:22][CH2:23][N:18]2[N:17]=1

참가 물질

반응물 3

HCID 699934-Methyloxybenzyl chloride

HCID 58465837Ethyl 5-(cyclopropylmethyl)-4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate

HCID 679759505-cyclopropylmethyl-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

생성물 1

HCID 679744372-Hydroxymethyl-5-(4-methoxy-benzyl)-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one

실험 절차

The compound was prepared from 1-(3-tert-butoxycarbonylaminoethyl)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester and 4-methoxybenzyl chloride using the methods described in the preceding examples 49 (5-cyclopropylmethyl-4-oxo-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyrazine-2-carboxylic acid ethyl ester) and 50 (5-cyclopropylmethyl-2-hydroxymethyl-6,7-dihydro-5H-pyrazolo[1,5-a]pyrazin-4-one).