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1-benzyl-N-methylpiperidin-4-amine → N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide

HRID 2046361
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HRID 2046361 반응식
C(N1CCC(NC)CC1)C1C=CC=CC=1.[CH2:16]([N:23]1[CH2:28][CH2:27][CH:26]([N:29]([CH3:42])[C:30](=[O:41])[CH2:31][O:32][C:33]2[N:38]=[C:37]([CH3:39])[CH:36]=[C:35]([CH3:40])[N:34]=2)[CH2:25][CH2:24]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[ClH:43].C(OCC)(=O)C>CO>[CH2:16]([N:23]1[CH2:28][CH2:27][CH:26]([N:29]([CH3:42])[C:30](=[O:41])[CH2:31][O:32][C:33]2[N:38]=[C:37]([CH3:39])[CH:36]=[C:35]([CH3:40])[N:34]=2)[CH2:25][CH2:24]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1.[ClH:43].[CH2:16]([N:23]1[CH2:28][CH2:27][CH:26]([N:29]([CH3:42])[C:30](=[O:41])[CH2:31][O:32][C:33]2[N:38]=[C:37]([CH3:39])[CH:36]=[C:35]([CH3:40])[N:34]=2)[CH2:25][CH2:24]1)[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 41361281-benzyl-N-methylpiperidin-4-amineHCID 21866389Hydrogen chloride-ethyl acetateHCID 59336186N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide

생성물 2

HCID 59336186N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide수율 62%
HCID 68416141
N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide (147 mg: 62% yield) was synthesized from 2-(4,6-dimethylpyrimidine-2-yl)oxyaceteic acid (117 mg) and 1-benzyl-N-methylpiperidine-4-amine (131 mg) in the same manner as in Example 49. Then, to a methanol solution of N-(1-benzylpiperidine-4-yl)-2-(4,6-dimethylpyrimidine-2-yloxy)-N-methylacetamide, 1 equivalent of 4N HCl/ethyl acetate solution was added. The mixture was then concentrated under reduced pressure to give the desired product as a white amorphous.

후처리

  1. concentrationThe mixture was then concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-eb05590aaee24dea8f14e4a36b59b39c
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08592435B2

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