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HCID 58046435, 화합물 → (1S,6R)-6-amino-2,2-difluorocyclohexanol

HRID 2046396
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HRID 2046396 반응식
[F:1][C:2]1([F:18])[CH2:7][CH2:6][CH2:5][C@@H:4]([NH:8][C@@H](C2C=CC=CC=2)C)[C@@H:3]1[OH:17]>CO.[OH-].[OH-].[Pd+2]>[NH2:8][C@H:4]1[C@H:3]([OH:17])[C:2]([F:18])([F:1])[CH2:7][CH2:6][CH2:5]1
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참가 물질

4

반응물 1

HCID 58046435HCID 58046435, 화합물

생성물 1

HCID 58046455(1S,6R)-6-amino-2,2-difluorocyclohexanol

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 887Methanol용매

실험 절차

A solution of (1S,6R)-2,2-difluoro-6-{[(1R)-1-phenylethyl]amino}cyclohexanol (2.0 g, 7.8 mmol) in methanol (100 mL) was degassed with nitrogen, treated with Pd(OH)2/C (0.55 g) and then placed under an atmosphere of hydrogen and stirred vigorously for 16 hours. The reaction was filtered, washed with methanol, and the filtrate evaporated in vacuo to afford the title compound as a white solid: 1H NMR (500 MHz, CD3OD) δ 3.34 (m, 1H); 2.74 (m, 1H); 2.07 (m, 1H); 1.89 (m, 1H); 1.73 (m, 2H); 1.50 (m, 1H); 1.27 (m, 1H).

후처리

  1. filtrationThe reaction was filtered
  2. washwashed with methanol
  3. customthe filtrate evaporated in vacuo

출처 및 근거

ORD 기록
ord-5948e9a9a313489b988619dd75daa21c
출처 데이터셋
uspto-grants-2013_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08592425B2

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