Water → 2-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one

HRID 2046451노트

반응식

HRID 2046451 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][C:12](=O)[C:11](=[CH:15]N(C)C)[C:10](=[O:19])[CH2:9]2)=[CH:4][CH:3]=1.Cl.[NH2:21][C:22]([NH2:24])=[NH:23].C(=O)([O-])[O-].[Na+].[Na+].O>C(O)C>[NH2:23][C:22]1[N:24]=[CH:15][C:11]2[C:10](=[O:19])[CH2:9][CH:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)[CH2:13][C:12]=2[N:21]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 5742Guanidine HydrochlorideHCID 10340Sodium CarbonateHCID 5670705-(4-Chlorophenyl)-2-[(dimethylamino)methylene]-1,3-cyclohexanedione

생성물 1

HCID 27723712-amino-7-(4-chlorophenyl)-7,8-dihydroquinazolin-5(6H)-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

5-(4-Chloro-phenyl)-2-dimethylaminomethylene-cyclohexane-1,3-dione (0.8 g, 2.89 mmol) from stage 1, guanidine hydrochloride (551 mg, 5.77 mmol) and sodium carbonate (919 mg, 8.67 mmol) were stirred in ethanol (10 ml) at reflux for 4 h. The reaction mixture was cooled to ambient temperature and water (10 ml) was added to the flask. The resulting precipitate was recovered by filtration, washed with water (15 ml), heptane (15 ml) and air dried.

후처리

  1. temperatureat reflux for 4 h
  2. filtrationThe resulting precipitate was recovered by filtration
  3. washwashed with water (15 ml), heptane (15 ml) and air
  4. customdried

출처 및 근거

ORD 기록
ord-e209105160994304acc27b198ef271aa
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592430B2

반응 노트

불러오는 중…