Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 2-Chloromaleic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Gantacurium | HCID 10102486 | — |
| 반응물 | Chlorofumarate | HCID 21982578 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 2-Chloromaleic acid | HCID 5284488 | — |
반응 단계
Gantacurium, an asymmetrical chlorofumarate, was prepared in four chemical transformations from compound (XIIIB) using minor modifications of previously reported chemistry, see WO2005/041960. Isoquinolylalkanol compound (XIIIB) was condensed with trans-2,3-dichlorosuccinic anhydride and triethylamine in acetonitrile solvent to provide a monoester of chlorofumaric acid, which was then condensed with isoquinolylalkanol compound (XIIIC):
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08592451B2 |
| 출처 데이터셋 | uspto-grants-2013_11 |
| ORD ID | ord-bfa23cbf96724e8aae7a97aca570a95b |
| 출처 메모 | uspto-grants-2013_11 |