HCID 59226578, 화합물 → (4R)-4-(hydroxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one

HRID 2046828노트

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HRID 2046828 반응식
C([O:8][CH2:9][C@@H:10]1[CH:14]([CH:15]([CH3:18])[CH2:16][OH:17])[O:13][C:12](=[O:19])[NH:11]1)C1C=CC=CC=1>CO.[Pd]>[OH:8][CH2:9][C@@H:10]1[CH:14]([CH:15]([CH3:18])[CH2:16][OH:17])[O:13][C:12](=[O:19])[NH:11]1

참가 물질

4

반응물 1

HCID 59226578HCID 59226578, 화합물

생성물 1

HCID 59226593(4R)-4-(hydroxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one수율 99%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of (4R)-4-(benzyloxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one (1.0 equiv.) in methanol, at a concentration of 0.1 M, was added 10% palladium on carbon (0.1 eq.). The resultant heterogeneous solution was put under an atmosphere of hydrogen and was stirred for 15 hours. At this time the mixture was filtered through a pad of celite eluting with methanol. The volatiles were removed in vacuo yielding (4R)-4-(hydroxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one (99%). LCMS (m/z): 176.1 (MH+).

후처리

  1. filtrationAt this time the mixture was filtered through a pad of celite
  2. washeluting with methanol
  3. customThe volatiles were removed in vacuo

출처 및 근거

ORD 기록
ord-2e12e7be5d72454d95552fc767646710
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592455B2

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