p-Toluenesulfonic acid → N2-(2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)phenyl)-N6-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purine-2,6-diamine

HRID 2046998노트

반응식

HRID 2046998 반응식
Cl[C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:11])[CH:7]=[N:8]2)=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])[N:3]=1.[CH:25]([O:28][C:29]1[CH:35]=[C:34]([CH:36]2[CH2:41][CH2:40][N:39]([CH3:42])[CH2:38][CH2:37]2)[C:33]([CH3:43])=[CH:32][C:30]=1[NH2:31])([CH3:27])[CH3:26].CC1C=CC(S(O)(=O)=O)=CC=1>C(O)(C)C>[CH:25]([O:28][C:29]1[CH:35]=[C:34]([CH:36]2[CH2:37][CH2:38][N:39]([CH3:42])[CH2:40][CH2:41]2)[C:33]([CH3:43])=[CH:32][C:30]=1[NH:31][C:2]1[N:10]=[C:9]2[C:5]([N:6]([CH3:11])[CH:7]=[N:8]2)=[C:4]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[S:19]([CH:22]([CH3:24])[CH3:23])(=[O:21])=[O:20])[N:3]=1)([CH3:27])[CH3:26]

참가 물질

5

반응물 3

HCID 6101p-Toluenesulfonic acidHCID 582908802-chloro-N-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purin-6-amineHCID 597643702-Isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)aniline

생성물 1

HCID 58290896N2-(2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)phenyl)-N6-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purine-2,6-diamine

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
150 °C

실험 절차

To a suspension of 2-chloro-N-(2-(isopropylsulfonyl)phenyl)-7-methyl-7H-purin-6-amine (1 equivalent) in isopropanol, was added 2-isopropoxy-5-methyl-4-(1-methylpiperidin-4-yl)aniline (1 equivalent) and 4-methylbenzenesulfonic acid (1 equivalent). The suspension was stirred at 150° C. for 3 hours, cooled to room temperature and the solvent evaporated. The residue was purified using a preparative HPLC to afford the desired product as a gummy solid.

후처리

  1. temperaturecooled to room temperature
  2. customthe solvent evaporated
  3. customThe residue was purified

출처 및 근거

ORD 기록
ord-8329caf415e346039efed7822a46eeb6
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592432B2

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