HCID 67494680, 화합물 → HCID 178497545, 화합물

HRID 2047015노트

반응식

HRID 2047015 반응식
[CH3:1][O:2][C:3]([CH:5]1[CH2:10][CH2:9][CH:8]([C:11](=O)[CH2:12][C:13]([O:15]CC)=O)[CH2:7][CH2:6]1)=[O:4].[NH2:19][C:20]1[CH:24]=[CH:23][NH:22][N:21]=1>ClCCl>[CH3:1][O:2][C:3]([CH:5]1[CH2:6][CH2:7][CH:8]([C:11]2[CH:12]=[C:13]([OH:15])[N:21]3[N:22]=[CH:23][CH:24]=[C:20]3[N:19]=2)[CH2:9][CH2:10]1)=[O:4]

참가 물질

4

반응물 2

HCID 67494680HCID 67494680, 화합물HCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178497545HCID 178497545, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
100 °C

실험 절차

4-(2-Ethoxycarbonyl-acetyl)-cyclohexanecarboxylic acid methyl ester (8.5 g) and 3-amino-1H-pyrazole (26.5 mmol, 2.2 g) were mixed and heated neat at 100° C. for 16 hours. The resulting residue is dissolved in dichloromethane (100 mL) and concentrated in vacuo to remove water formed during cyclization. This solid is taken forward without further purification. LC-MS: 403 [M+H].

후처리

  1. concentrationconcentrated in vacuo
  2. customto remove water
  3. customformed during cyclization
  4. customThis solid is taken forward without further purification

출처 및 근거

ORD 기록
ord-c252108c2c4d4684825c38a86395462c
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08591943B2

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