Triethylamine → HCID 67494673, 화합물

HRID 2047027노트

반응식

HRID 2047027 반응식
[CH:1]1([S:4](Cl)(=[O:6])=[O:5])[CH2:3][CH2:2]1.[Br:8][C:9]1[C:10]([O:29][CH2:30][CH:31]2[CH2:36][CH2:35][NH:34][CH2:33][CH2:32]2)=[N:11][C:12]2[N:13]([N:16]=[CH:17][C:18]=2[C:19]2[CH:20]=[N:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:14]=1[NH2:15].C(N(CC)CC)C>CN(C=O)C>[Br:8][C:9]1[C:10]([O:29][CH2:30][CH:31]2[CH2:32][CH2:33][N:34]([S:4]([CH:1]3[CH2:3][CH2:2]3)(=[O:6])=[O:5])[CH2:35][CH2:36]2)=[N:11][C:12]2[N:13]([N:16]=[CH:17][C:18]=2[C:19]2[CH:20]=[N:21][C:22]3[C:27]([CH:28]=2)=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:14]=1[NH2:15]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 2760919Cyclopropanesulfonyl chlorideHCID 67494200HCID 67494200, 화합물

생성물 1

HCID 67494673HCID 67494673, 화합물수율 34.7%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

Cyclopropanesulfonyl chloride (24 mg, 0.167 mmol) was added into a solution of 6-bromo-5-(piperidin-4-ylmethoxy)-3-(quinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine (50 mg, 0.111 mmol) and triethylamine (56 mg, 0.553 mmol) in DMF at room temperature. The resulting reaction mixture was stirred at room temperature for 16 h, concentrated and purified by prep-LC to afford the title compound (21.5 mg): LC/MS RT=4.17 min. Mass calculated for, M+H 557.09, observed 557.09.

후처리

  1. customThe resulting reaction mixture
  2. concentrationconcentrated
  3. custompurified by prep-LC

출처 및 근거

ORD 기록
ord-07518cd76a60469ba7bdabc0720406bb
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08591943B2

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