Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate → HCID 178515484, 화합물

HRID 2047054노트

반응식

HRID 2047054 반응식
O=[C:2]([CH:9]1[CH2:18][CH2:17][C:12]2([O:16][CH2:15][CH2:14][O:13]2)[CH2:11][CH2:10]1)[CH2:3][C:4]([O:6]CC)=O.[NH2:19][C:20]1[CH:24]=[CH:23][NH:22][N:21]=1>CCO>[O:13]1[C:12]2([CH2:11][CH2:10][CH:9]([C:2]3[CH:3]=[C:4]([OH:6])[N:21]4[N:22]=[CH:23][CH:24]=[C:20]4[N:19]=3)[CH2:18][CH2:17]2)[O:16][CH2:15][CH2:14]1

참가 물질

4

반응물 2

HCID 66733231Ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoateHCID 178418806HCID 178418806, 화합물

생성물 1

HCID 178515484HCID 178515484, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

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온도
100 °C

실험 절차

To a 20 mL scintillation vial containing ethyl 3-oxo-3-(1,4-dioxaspiro[4.5]decan-8-yl)propanoate (11.7 mmol, 3.00 g) is added 3-amino-1H-pyrazole (11.7 mmol, 973 mg). The two oils were mixed and heated neat at 100° C. for 3 hours. The resulting off-white solid was dissolved up in EtOH (100 mL) and reduced in vacuo to remove water formed during cyclization. This solid was used in the next step without further purification.

후처리

  1. additionThe two oils were mixed
  2. customto remove water
  3. customformed during cyclization
  4. customThis solid was used in the next step without further purification

출처 및 근거

ORD 기록
ord-9f8dc6d1a07f461ab43307203fe1e194
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08591943B2

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