(R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester → HCID 68562078, 화합물
반응식
[C:1]([O:5][C:6]([N:8]1[CH:13]([CH:14]([O:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[CH:15]([N:25]([CH2:33][C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@@H:10]([OH:48])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:49][CH2:50][C:51]1([CH2:56]OS(C(F)(F)F)(=O)=O)[CH2:55][CH2:54][CH2:53][CH2:52]1>>[C:1]([O:5][C:6]([N:8]1[C@@H:13]([C@@H:14]([O:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[C@@H:15]([N:25]([CH2:26][C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH2:33][C:34]2[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=2)[CH2:16][C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[C:19]([F:24])[CH:18]=2)[CH2:12][O:11][C@@H:10]([O:48][CH2:56][C:51]2([CH2:50][F:49])[CH2:55][CH2:54][CH2:53][CH2:52]2)[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]참가 물질
3
실험 절차
Beginning with (R)-5-[1-benzyloxy-2-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-hydroxymorpholine-4-carboxylic acid tert-butyl ester and trifluoromethane-sulfonic acid 1-fluoromethyl-cyclopentylmethyl ester, the desired compound may be prepared essentially as described in Preparation 306.
출처 및 근거
- ORD 기록
- ord-c56912b0849943d6a64374458acfdae2