Water → HCID 86664792, 화합물

HRID 2047209노트

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HRID 2047209 반응식
Br[C:2]1[C:3](CNC2C[C@H](C)O[C@H](C)C2)=[N:4][C:5]2[N:6]([N:25]=[CH:26][C:27]=2[C:28]2[CH:29]=[N:30][C:31]3[C:36]([CH:37]=2)=[CH:35][C:34]([F:38])=[CH:33][CH:32]=3)[C:7]=1[N:8](COCC[Si](C)(C)C)COCC[Si](C)(C)C.O>C(O)(C(F)(F)F)=O>[F:38][C:34]1[CH:35]=[C:36]2[C:31](=[CH:32][CH:33]=1)[N:30]=[CH:29][C:28]([C:27]1[CH:26]=[N:25][N:6]3[C:7]([NH2:8])=[CH:2][CH:3]=[N:4][C:5]=13)=[CH:37]2

참가 물질

4

반응물 2

HCID 962Water2회HCID 66738579HCID 66738579, 화합물

생성물 1

HCID 86664792HCID 86664792, 화합물

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매2회

실험 절차

To a 6-bromo-5-(((2R,6S)-2,6-dimethyltetrahydro-2H-pyran-4-ylamino)methyl)-3-(6-fluoroquinolin-3-yl)-N,N-bis((2-(trimethylsilyl)ethoxy)methyl)pyrazolo[1,5-a]pyrimidin-7-amine (69.3 mg, 0.09 mmol) in TFA (2 ml) was added few drops of water and stirring continued for 2 h at room temperature. LC/MS showed no starting material remaining. TFA along with water was rotoevaporated. This crude compound was submitted to the analytical group for purification to afford the desired 6-bromo-5-((2R,6S)-2,6-dimethyltetrahydro-2H-pyran-4-ylamino)methyl)-3-(6-fluoroquinolin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine. LCMS: 3.157 mins, m/z=499.0 (MH+).

후처리

  1. customThis crude compound was submitted to the analytical group for purification

출처 및 근거

ORD 기록
ord-e16a100fe6fa494388fc67a66362a1c6
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08591943B2

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