2-Methyl-6-(morpholin-4-yl)isonicotinic acid → 3-{2-Ethyl-6-methyl-4-[5-(2-methyl-6-morpholin-4-yl-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-phenyl}-propionic acid
반응식
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)[N:10]=1)[C:5]([OH:7])=O.C([O:21][C:22](=[O:38])[CH2:23][CH2:24][C:25]1[C:30]([CH3:31])=[CH:29][C:28]([C:32](=[NH:35])[NH:33]O)=[CH:27][C:26]=1[CH2:36][CH3:37])(C)(C)C>>[CH2:36]([C:26]1[CH:27]=[C:28]([C:32]2[N:33]=[C:5]([C:4]3[CH:8]=[C:9]([N:11]4[CH2:16][CH2:15][O:14][CH2:13][CH2:12]4)[N:10]=[C:2]([CH3:1])[CH:3]=3)[O:7][N:35]=2)[CH:29]=[C:30]([CH3:31])[C:25]=1[CH2:24][CH2:23][C:22]([OH:38])=[O:21])[CH3:37]참가 물질
3
실험 절차
The title compound is prepared in analogy to Example 8 from 2-methyl-6-morpholin-4-yl-isonicotinic acid and 3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenyl]-propionic acid tert-butyl ester; LC-MS: tR=0.98 min; [M+1]+=437.25.
출처 및 근거
- ORD 기록
- ord-a44135c3140141fe9a1841be38771806
- 출처 데이터셋