N-(2-amino-phenyl)-5-bromo-2-fluoro-benzamide → 2-(5-Bromo-2-fluoro-phenyl)-1H-benzoimidazole
반응식
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9](=O)[C:10]1[CH:15]=[C:14]([Br:16])[CH:13]=[CH:12][C:11]=1[F:17]>C(O)(=O)C>[Br:16][C:14]1[CH:13]=[CH:12][C:11]([F:17])=[C:10]([C:9]2[NH:8][C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=2)[CH:15]=1참가 물질
3
반응 조건
- 온도
- 60 °C
실험 절차
A suspension of N-(2-amino-phenyl)-5-bromo-2-fluoro-benzamide (5.64 g, 18.3 mmol) in acetic acid (20 mL) was heated at 60° C. After 30 min, the suspension became a solution and it was left overnight. The solvent was removed under reduced pressure and residue was triturated with DCM (10 mL) and filtered off. The precipitate was washed with DCM (3×10 mL) and dried to afford 4.76 g of the title compound (89%).
후처리
- waitwas left overnight
- customThe solvent was removed under reduced pressure and residue
- customwas triturated with DCM (10 mL)
- filtrationfiltered off
- washThe precipitate was washed with DCM (3×10 mL)
- customdried
출처 및 근거
- ORD 기록
- ord-a0020226a2894bd2a1ecc68c4a8d1139
- 출처 데이터셋
- uspto-grants-2013_11
- 특허 번호
- US08592463B2
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