참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Oxalic Acid | HCID 971 | — |
| 반응물 | 3-Bromobenzaldehyde | HCID 76583 | — |
| 반응물 | 1,2-Diaminobenzene (D4, 98%) | HCID 10772950 | — |
| 용매 | Water ethanol | HCID 19096565 | — |
| 생성물 | 2-(3-Bromophenyl)benzimidazole | HCID 278822 | 26.6% |
반응 단계
O-phenylenediamine (81.8 g, 756.6 mmol) and oxalic acid (3.4 g, 37.8 mmol) were completely dissolved in EtOH—H2O/1:1 (2 L) previously warmed at 80° C. 3-Bromobenzaldehyde (44.10 mL, 378.30 mmol) was then added dropwise to the solution. The reaction mixture was stirred overnight at 70° C. to the open air. The day after solid was filtered off and triturated with MeOH (150 mL) to give the product as a pale yellow solid (27.50 g). 3.8 g were recovered from the mother liquors. Total yield 31.30 g (30%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08592463B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_11 |
|---|
| ORD ID | ord-22885e3db09647e7ade31aa8bd08e47d |
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| 출처 메모 | uspto-grants-2013_11 |
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