1,3-Cyclohexanedione → Indole

HRID 2047580

반응식

HRID 2047580 반응식
C1(=O)CCCC(=O)C1.C1[C:21]2[NH:20][C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]=2C(=O)CC1>>[NH:20]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=[CH:21]1

참가 물질

3

반응물 2

HCID 104341,3-CyclohexanedioneHCID 9291301,2,3,9-Tetrahydro-4H-carbazol-4-one

생성물 1

HCID 798Indole

반응 조건

온도
25 °C

실험 절차

A 0.25 mol/L 1,3-cyclohexanedione/50% sulfuric acid solution was placed in a 200-mL container purged with nitrogen. Then, a 0.25 mol/L phenylhydrazine/50% sulfuric acid solution was added dropwise into the container under stirring at 20000 rpm by CLEARMIX (manufactured by M Technique Co., Ltd.) while the temperature of the liquid in the container was maintained at 25° C. As a result of HPLC analysis, the production rate of 1,2,3,4-tetrahydrocarbazol-4-one was 24% or less.

후처리

  1. custompurged with nitrogen
  2. additionThen, a 0.25 mol/L phenylhydrazine/50% sulfuric acid solution was added dropwise into the container
  3. customAs a result of HPLC analysis

출처 및 근거

ORD 기록
ord-5caa892205f740fab9be722cc36b6182
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592498B2

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