Dimethylformamide → 1-Bromo-5-(but-3-enyloxy)-2,4-dimethylbenzene

HRID 2047947

반응식

HRID 2047947 반응식
[Br:1][C:2]1[C:3]([CH3:10])=[CH:4][C:5]([CH3:9])=[C:6]([OH:8])[CH:7]=1.CN(C)C=O.C(=O)([O-])[O-].[K+].[K+].Br[CH:23]=[CH:24][CH2:25][CH3:26]>O>[Br:1][C:2]1[CH:7]=[C:6]([O:8][CH2:26][CH2:25][CH:24]=[CH2:23])[C:5]([CH3:9])=[CH:4][C:3]=1[CH3:10]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 11430Potassium CarbonateHCID 359451-Bromobut-1-eneHCID 126177325-Bromo-2,4-dimethylphenol

생성물 1

HCID 594796111-Bromo-5-(but-3-enyloxy)-2,4-dimethylbenzene

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
95 °C

실험 절차

A 250-mL round bottomed flask is charged with 5-bromo-2,4-dimethylphenol (3.135 g, 15.6 mmol) and dimethylformamide (DMF) (50 mL). Potassium carbonate (23.7 g, 172 mmol) and bromobutene (15.8 mL, 156 mmol) are added and the reaction mixture is heated to 95° C. for 2 hr. After cooling to room temp, water (200 mL) is added. The product is extracted into ether (2×100 mL), and the combined organic fractions are washed with brine, dried over sodium sulfate and dried in vacuo. Yield=3.63 g (91.3%) of light yellow liquid.

후처리

  1. temperatureAfter cooling to room temp
  2. extractionThe product is extracted into ether (2×100 mL)
  3. washthe combined organic fractions are washed with brine
  4. dry with materialdried over sodium sulfate
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-eba2d7c18d024c388c7a982b46f758d0
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592615B2

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