Cyclopropylboronic acid → HCID 58042362, 화합물

HRID 2048086노트

반응식

HRID 2048086 반응식
[F:1][CH:2]([F:11])[O:3][C:4]1[C:5](Br)=[N:6][CH:7]=[CH:8][CH:9]=1.[CH:12]1(B(O)O)[CH2:14][CH2:13]1>>[F:1][CH:2]([F:11])[O:3][C:4]1[C:5]([CH:12]2[CH2:14][CH2:13]2)=[N:6][CH:7]=[CH:8][CH:9]=1

참가 물질

3

반응물 2

HCID 2760897Cyclopropylboronic acidHCID 580424482-broMo-3-(difluoroMethoxy)pyridine

생성물 1

HCID 58042362HCID 58042362, 화합물수율 58%

반응 조건

온도
95 °C

실험 절차

Prepared according to Preparation 48 using 3-difluoromethoxy-2-bromopyridine (Preparation 217) and cyclopropylboronic acid. The reaction was heated to 95° C. for 18 hours before cooling to room temperature and filtering through arbocel. The filtrate was concentrated in vacuo and purified using silica gel column chromatography eluting with ethylacetate:heptane 1:5 to furnish the title compound as a colourless oil (273 mg, 58%).

후처리

  1. customPrepared
  2. temperaturebefore cooling to room temperature
  3. filtrationfiltering through arbocel
  4. concentrationThe filtrate was concentrated in vacuo
  5. custompurified
  6. washeluting with ethylacetate:heptane 1:5

출처 및 근거

ORD 기록
ord-79a046edaf4f4bf7a1ebb93ad6927f28
출처 데이터셋
uspto-grants-2013_11
특허 번호
US08592629B2

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