Potassium Iodide → N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine

HRID 2049060노트

반응식

HRID 2049060 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][CH:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]1.C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+].I[CH2:25][CH2:26][CH3:27]>O.C1C=CC=CC=1>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][CH:10]1[CH2:15][CH2:14][N:13]([CH2:25][CH2:26][CH3:27])[CH2:12][CH2:11]1

참가 물질

7

반응물 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 336431-IodopropaneHCID 23339004N-(2,6-Dimethylphenyl)piperidin-4-amine

생성물 1

HCID 23339025N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine

시약·촉매·용매 2

HCID 241Benzene용매2회HCID 962Water용매

반응 조건

온도
40 °C

실험 절차

To a warm (about 40° C.) and stirred mixture of 5 parts of N-(2,6-dimethylphenyl)-4-piperidinamine, 5 parts of sodium carbonate, a few crystals of potassium iodide in 120 parts of benzene is added dropwise a solution of 5.1 parts of 1-iodopropane in 80 parts of benzene. After the addition is complete, stirring is continued for 40 hours at reflux temperature. The reaction mixture is cooled and 50 parts of water are added. The organic layer is separated, dried and evaporated in vacuo. The oily residue is distilled, yielding 10.2 parts of N-(2,6-dimethylphenyl)-1-propyl-4-piperidinamine; bp. 135° C. at 0.2 mm. pressure.

후처리

  1. additionAfter the addition
  2. stirringstirring
  3. temperatureat reflux temperature
  4. temperatureThe reaction mixture is cooled
  5. customThe organic layer is separated
  6. customdried
  7. customevaporated in vacuo
  8. distillationThe oily residue is distilled

출처 및 근거

ORD 기록
ord-e2d8b4da3982470bb62499fb70610008
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04196210

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