2-(Methylthio)benzothiazole → 3-(4-Octadecyloxycarbonylbenzyl)benzothiazoline-2-thione
반응식
[CH2:1]([O:19][C:20]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26]Br)=[CH:24][CH:23]=1)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].C[S:31][C:32]1[S:33][C:34]2[CH:40]=[CH:39][CH:38]=[CH:37][C:35]=2[N:36]=1>>[CH2:1]([O:19][C:20]([C:22]1[CH:29]=[CH:28][C:25]([CH2:26][N:36]2[C:35]3[CH:37]=[CH:38][CH:39]=[CH:40][C:34]=3[S:33][C:32]2=[S:31])=[CH:24][CH:23]=1)=[O:21])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]참가 물질
3
실험 절차
4-Octadecyloxycarbonylbenzyl bromide (4.7 g, Step 2) and 2-methylmercaptobenzothiazole (2.5 g) were heated together for 35 minutes/190°-195° C. The mixture was cooled and triturated with ligroin to produce a solid which was recrystallized from pyridine/methanol to form the product; yield 4.5 g (81%), m.p. 105°-107° C.
후처리
- temperatureThe mixture was cooled
- customtriturated with ligroin
- customto produce a solid which
- customwas recrystallized from pyridine/methanol
- customto form the product