Bis(dichloromethyl) ether → alpha-Sulfo-3-(chloromethyl)-4-hydroxybenzeneacetic acid

HRID 2049212노트

반응식

HRID 2049212 반응식
[S:1]([CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[CH:11][CH:10]=1)[C:6]([OH:8])=[O:7])([OH:4])(=[O:3])=[O:2].[Cl:16][CH:17](OC(Cl)Cl)Cl>S(=O)(=O)(O)O>[S:1]([CH:5]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([CH2:17][Cl:16])[CH:10]=1)[C:6]([OH:8])=[O:7])([OH:4])(=[O:3])=[O:2]

참가 물질

4

반응물 2

HCID 558102Bis(dichloromethyl) etherHCID 3373694(4-Hydroxy-phenyl)-sulfo-acetic acid

생성물 1

HCID 20296128alpha-Sulfo-3-(chloromethyl)-4-hydroxybenzeneacetic acid

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

α-Sulfo-4-hydroxybenzeneacetic acid, 0.3 mole, is dissolved in aqueous sulfuric acid (50%). One equivalent of dichloromethyl ether is added to the solution maintained at between 35° to 45° C. Hydrogen chloride is then bubbled through this reaction mixture for 3 hours. The desired compound is recovered by pouring the reaction mixture into water and extracting the title compound with ethyl acetate. The ethyl acetate is dried over magnesium sulfate. The magnesium sulfate is removed by filtration and evaporation of the ethyl acetate gives the desired compound.

후처리

  1. temperaturemaintained at between 35° to 45° C
  2. customHydrogen chloride is then bubbled through this reaction mixture for 3 hours
  3. customThe desired compound is recovered
  4. additionby pouring the reaction mixture into water
  5. extractionextracting the title compound with ethyl acetate
  6. dry with materialThe ethyl acetate is dried over magnesium sulfate
  7. customThe magnesium sulfate is removed by filtration and evaporation of the ethyl acetate

출처 및 근거

ORD 기록
ord-880fdde6fce944ba898a8dc841a34523
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04197240

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