Ethanone, 2-chloro-1,2-diphenyl- → 2-(3,4-Methylenedioxyphenyl)-4,5-diphenylthiazole

HRID 2049275

반응식

HRID 2049275 반응식
[C:1]([NH2:12])(=[S:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[C:13]1([C:19]([CH:21](Cl)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[CH2:6]1[O:7][C:8]2[CH:9]=[CH:10][C:2]([C:1]3[S:11][C:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[N:12]=3)=[CH:3][C:4]=2[O:5]1

참가 물질

4

반응물 2

HCID 95343Ethanone, 2-chloro-1,2-diphenyl-HCID 27761262H-1,3-benzodioxole-5-carbothioamide

생성물 1

HCID 203449832-(3,4-Methylenedioxyphenyl)-4,5-diphenylthiazole수율 67.1%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Thiopiperonylamide (18.1 g, 0.10 mole) and desyl chloride (23.1 g, 0.10 mole) are heated under reflux in 95% ethanol (100 ml) for two hours. An oil precipitates which solidifies when the reaction mixture is cooled. The solid is collected and recrystallized from ethanolethyl acetate to give 24.0 g (67% yield ) of 2-(3,4-methylenedioxyphenyl)-4,5-diphenylthiazole, m.p. 121°-124° C. Thiopiperonylamide is also prepared from the corresponding nitrile by the method of Fairfull et al., J. Chem. Soc. 1952, 742.

후처리

  1. customAn oil precipitates which
  2. temperatureis cooled
  3. customThe solid is collected
  4. customrecrystallized from ethanolethyl acetate

출처 및 근거

ORD 기록
ord-52f6e35e790d48d48e59f5d026142358
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04197306

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