Formaldehyde → isopropyl N-(methylaminomethyl)carbamate hydrochloride
반응식
[ClH:1].[CH3:2][NH2:3].[CH2:4]=O.[C:6](=[O:12])([O:8][CH:9]([CH3:11])[CH3:10])[NH2:7]>C(O)C>[ClH:1].[CH3:2][NH:3][CH2:4][NH:7][C:6](=[O:12])[O:8][CH:9]([CH3:11])[CH3:10]참가 물질
5
실험 절차
To 50 ml of ethanol, 20.3 g (0.3 mole) of methylamine hydrochloride and 30.9 g (0.36 mole) of 37% formaldehyde aqueous solution were added and the mixture was warmed to 35°-40° C. Then, a solution prepared by dissolving 30.9 g (0.3 mole) of isopropyl carbamate in 150 ml of ethanol was added dropwise to the mixture with stirring maintaining the said temperature. After the dropwise addition of the solution, stirring was continued for 1 hour with heating and then the solvent was removed by distillation under reduced pressure. The residue was recrystallized from ethanol to give 42.7 g of isopropyl N-(methylaminomethyl)carbamate hydrochloride having a melting point of 163°-164° C. in yield of 77.8%. ##STR5##