HCID 20344091, 화합물 → HCID 20344093, 화합물

HRID 2049633노트

반응식

HRID 2049633 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:16]=[CH:17][CH:18]=1)[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[CH2:12][C:13]([OH:15])=O>O>[F:1][C:2]1[CH:18]=[CH:17][C:16]2[C:13](=[O:15])[CH2:12][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[O:5][C:4]=2[CH:3]=1

참가 물질

3

반응물 1

HCID 20344091HCID 20344091, 화합물

생성물 1

HCID 20344093HCID 20344093, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-(3-Fluorophenoxy)benzeneacetic acid (22 g.) was added to 90 g. of polyphosphoric acid at 125°. The reaction mixture was stirred 1 hour at 125°. It was then cooled; water (300 ml) was added with stirring; a solid product was filtered and extracted with toluene several times. The combined toluene extracts were washed successively with water, dilute alkali, and water, then dried over magnesium sulfate and evaporated to yield the title compound as a solid product, which was purified upon treatment with hexane. ##STR15##

후처리

  1. customat 125°
  2. temperatureIt was then cooled
  3. stirringwith stirring
  4. filtrationa solid product was filtered
  5. extractionextracted with toluene several times
  6. washThe combined toluene extracts were washed successively with water
  7. additiondilute alkali, and water
  8. dry with materialdried over magnesium sulfate
  9. customevaporated

출처 및 근거

ORD 기록
ord-345b32881f654435a82c1ffd1be7e4fd
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04198421

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