Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 반응물 | 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyliden)ethanone | HCID 57153745 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone | HCID 20344142 | — |
반응 단계
11.8 g of lithium aluminum hydride are added portionwise at 0° with stirring to 144.8 g of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyliden)ethanone dissolved in 1.4 liters of tetrahydrofuran. 30 minutes after completion of the addition, 300 ml of water are cautiously added dropwise, with cooling; then 800 ml of diethyl ether are added, and the organic phase is collected. The organic phase is dried over sodium sulfate, the solvent is removed by evaporation, and the oily residue is distilled under a vacuum to obtain 127 g (87% of theory) of the title compound:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04198424 |
| 출처 데이터셋 | uspto-grants-1980_04 |
| ORD ID | ord-7820fc9e1cab48449fbfec1eb3cd7a56 |
| 출처 메모 | uspto-grants-1980_04 |