Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 1-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | 1-(3-Methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone | HCID 20344142 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 1-(3-Hydroxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone | HCID 20344140 | — |
반응 단계
40.5 of 1-(3-methoxyphenyl)-2-(1-methyl-2-pyrrolidinyl)ethanone are boiled under reflux for 6 hours with 180 ml of acetic acid and 180 ml of 47% hydrobromic acid. After concentration of the solution, the oily residue is brought to crystallization through treatment with 150 ml of hot ethanol. Cooling is allowed to take place, and 39.8 g (76% of theory) of the hydrobromide of the title compound is filtered off as greenish crystals: m.p. 165° to 168°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04198424 |
| 출처 데이터셋 | uspto-grants-1980_04 |
| ORD ID | ord-de4b1731d35c4d0a8b1e8f23c53058e2 |
| 출처 메모 | uspto-grants-1980_04 |