Potassium Hydroxide → 3-(4-Chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid

HRID 2049819노트

반응식

HRID 2049819 반응식
[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([O:6][CH:7]2[CH:9]([C:10]([O:12]CC)=[O:11])[C:8]2([CH3:16])[CH3:15])=[CH:4][CH:3]=1.[OH-].[K+]>O.C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH:7]2[CH:9]([C:10]([OH:12])=[O:11])[C:8]2([CH3:15])[CH3:16])=[CH:17][CH:18]=1

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 20344552Ethyl 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylate

생성물 1

HCID 203049613-(4-Chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

The ethyl 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylate (l.5 g) is hydrolyzed by heating under reflux with 10% potassium hydroxide in a mixture of 20% water and 80% ethyl alcohol for 1 hr and letting stand at 25° overnight. The solution is cooled and solvent is removed in vacuo. The residue is diluted with water and extracted with ether. The aqueous phase is then acidified with aqueous HCl and extracted with ether. The organic phase is washed with water and brine, dried over sodium sulfate and the solvent removed in vacuo to give 3-(4-chlorophenoxy)-2,2-dimethylcyclopropanecarboxylic acid.

후처리

  1. temperatureby heating
  2. customat 25°
  3. customovernight
  4. temperatureThe solution is cooled
  5. customsolvent is removed in vacuo
  6. additionThe residue is diluted with water
  7. extractionextracted with ether
  8. extractionextracted with ether
  9. washThe organic phase is washed with water and brine
  10. dry with materialdried over sodium sulfate
  11. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-5310d75bd8364f5e910f78e7533fafaa
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04198527

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