Isopropanol → Isopropyl 2-Chloro-4-Trifluoromethyl-5-Thiazolecarboxylate

HRID 2049934노트

반응식

HRID 2049934 반응식
[Cl:1][C:2]1[S:3][C:4]([C:11](Cl)=[O:12])=[C:5]([C:7]([F:10])([F:9])[F:8])[N:6]=1.[CH:14]([OH:17])([CH3:16])[CH3:15]>>[Cl:1][C:2]1[S:3][C:4]([C:11]([O:17][CH:14]([CH3:16])[CH3:15])=[O:12])=[C:5]([C:7]([F:8])([F:9])[F:10])[N:6]=1

참가 물질

3

반응물 2

HCID 3776IsopropanolHCID 132827442-Chloro-4-trifluoromethyl-5-thiazolecarbonyl chloride

생성물 1

HCID 13282745Isopropyl 2-Chloro-4-Trifluoromethyl-5-Thiazolecarboxylate수율 86.1%

실험 절차

The acid chloride of Example 16 (5.2 g), and 10 g of isopropanol were held at reflux for 16 hours. Excess alcohol was removed under reduced pressure. The residue was dissolved in 50 ml. of ether. The ether solution was washed with sodium bicarbonate, dried (MgSO4) and concentrated under reduced pressure. The crude product was distilled at 1 mm. on a Kugelrohr to give 4.9 g (86%) of the desired product as colorless liquid, nD25 =1.4655.

후처리

  1. temperatureat reflux for 16 hours
  2. customExcess alcohol was removed under reduced pressure
  3. dissolutionThe residue was dissolved in 50 ml
  4. washThe ether solution was washed with sodium bicarbonate
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated under reduced pressure
  7. distillationThe crude product was distilled at 1 mm

출처 및 근거

ORD 기록
ord-583b7ab5798d4539847396c5f03105d9
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04199506

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