Formic Acid → 2-[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]ethyl formate

HRID 2050029노트

반응식

HRID 2050029 반응식
[OH:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[O:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2.[CH:17](O)=[O:18]>CCOCC>[CH:17]([O:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:14]=[N:13][C:12]2[C:11](=[O:15])[NH:10][C:9]([NH2:16])=[N:8][C:7]1=2)=[O:18]

참가 물질

4

반응물 2

HCID 284Formic AcidHCID 135398513Acyclovir

생성물 1

HCID 1361209032-[(2-Amino-6-oxo-3,6-dihydro-9H-purin-9-yl)methoxy]ethyl formate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A solution of 9-(2-hydroxyethoxymethyl)guanine (4.73 g) in 97% formic acid (24 ml) was stirred at room temperature overnight. The amber solution was diluted with about 200 ml of dry ether and chilled. The resulting white precipitation was filtered, dried and recrystallized from dry dimethylformamide to give 9-(2-formyloxyethoxymethyl)guanine (3.6 g, m.p. 225°-227° C.).

후처리

  1. temperaturechilled
  2. customThe resulting white precipitation
  3. filtrationwas filtered
  4. customdried
  5. customrecrystallized from dry dimethylformamide

출처 및 근거

ORD 기록
ord-41defff4d2024b6aa349cdeabe9992e0
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04199574

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