Pyridine → m-Phenoxybenzyl alpha-isopropyl-4-trifluoromethoxyphenylacetate

HRID 2050088노트

반응식

HRID 2050088 반응식
[O:1]([C:8]1[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=1)[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH:22]([CH:25]([C:29]1[CH:34]=[CH:33][C:32]([O:35][C:36]([F:39])([F:38])[F:37])=[CH:31][CH:30]=1)[C:26](Cl)=[O:27])([CH3:24])[CH3:23]>C(Cl)Cl>[CH:22]([CH:25]([C:29]1[CH:34]=[CH:33][C:32]([O:35][C:36]([F:37])([F:38])[F:39])=[CH:31][CH:30]=1)[C:26]([O:12][CH2:11][C:10]1[CH:13]=[CH:14][CH:15]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:9]=1)=[O:27])([CH3:24])[CH3:23]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 262953-Phenoxybenzyl alcoholHCID 20343288HCID 20343288, 화합물

생성물 1

HCID 20343285m-Phenoxybenzyl alpha-isopropyl-4-trifluoromethoxyphenylacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a solution of m-phenoxybenzyl alcohol (1.89 g) and pyridine (1 ml) in methylene chloride (6 ml) is added a methylene chloride (7 ml) solution of α-isopropyl-4-trifluoromethoxyphenylacetyl chloride, prepared from the corresponding acid (2.46 g) as illustrated in Example 15. After stirring the reaction mixture overnight, it is washed with water, dilute hydrochloric acid solution, dilute potassium hydroxide solution, water and evaporated to an orange oil. Purification by silica gel chromatography gives the desired ester (2.76 g).

후처리

  1. washis washed with water, dilute hydrochloric acid solution, dilute potassium hydroxide solution, water
  2. customevaporated to an orange oil
  3. customPurification by silica gel chromatography

출처 및 근거

ORD 기록
ord-db7261bb0919436a9fe4ad734e5c6cfb
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04199595

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