Sodium Cyanide → 3-Fluoro-4-methoxyphenylacetonitrile
반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([F:11])[CH:4]=1.[CH2:12]([N:18](CCCCCC)CCCCCC)CCCCC.[C-]#N.[Na+]>O>[F:11][C:5]1[CH:4]=[C:3]([CH2:2][C:12]#[N:18])[CH:8]=[CH:7][C:6]=1[O:9][CH3:10]참가 물질
5
실험 절차
A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.
후처리
- temperatureis heated at 60°-65° C. for 18 hours
- temperatureThe mixture is cooled
- extractionextracted in its ether
- washwashed with water, saturated sodium chloride solution
- dry with materialdried (CNa2SO4)
- customEvaporation of the solvent
- customgives a solid, (33.2 g)
출처 및 근거
- ORD 기록
- ord-0b5c1373a8294b4196cf6dbc99e9e2f5
- 출처 데이터셋
- uspto-grants-1980_04
- 특허 번호
- US04199595
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