Sodium Cyanide → 3-Fluoro-4-methoxyphenylacetonitrile

HRID 2050096

반응식

HRID 2050096 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][CH3:10])=[C:5]([F:11])[CH:4]=1.[CH2:12]([N:18](CCCCCC)CCCCCC)CCCCC.[C-]#N.[Na+]>O>[F:11][C:5]1[CH:4]=[C:3]([CH2:2][C:12]#[N:18])[CH:8]=[CH:7][C:6]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 8929Sodium CyanideHCID 66022TrihexylamineHCID 27745534-(Bromomethyl)-2-fluoro-1-methoxybenzene

생성물 1

HCID 1362513-Fluoro-4-methoxyphenylacetonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 4-(bromomethyl)-2-fluoroanisole (45.8 g, 0.21 mol), trihexylamine (1.4 g) and sodium cyanide (20.5 g, 0.42 mol) in water (50 ml) is heated at 60°-65° C. for 18 hours. The mixture is cooled and extracted in its ether, washed with water, saturated sodium chloride solution and dried (CNa2SO4). Evaporation of the solvent gives a solid, (33.2 g): m.p. 42°-46° C.

후처리

  1. temperatureis heated at 60°-65° C. for 18 hours
  2. temperatureThe mixture is cooled
  3. extractionextracted in its ether
  4. washwashed with water, saturated sodium chloride solution
  5. dry with materialdried (CNa2SO4)
  6. customEvaporation of the solvent
  7. customgives a solid, (33.2 g)

출처 및 근거

ORD 기록
ord-0b5c1373a8294b4196cf6dbc99e9e2f5
출처 데이터셋
uspto-grants-1980_04
특허 번호
US04199595

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